Polycaprolactone/Gelatin Nanofibrous Scaffolds for Tissue Engineering
Saeed Farzamfar, Mehdi Aleahmad, Gholamreza Savari Kouzehkonan, Majid Salehi, Niloofar Nazeri, S Keshtkar, N Azarpira, M Ghahremani, N Nazeri, R Karimi, H Ghanbari, S Ahsan, M Thomas, K Reddy, S Sooraparaju, A Asthana, I Bhatnagar, G Turnbull, J Clarke, F Picard, P Riches, L Jia, F Han, B Li, W Shu, U Jammalamadaka, K Tappa, A Armiento, M Stoddart, M Alini, D Eglin, R Palchesko, S Carrasquilla, A Feinberg, S Ranganathan, K Balagangadharan, N Selvamurugan, B Pollot, C Rathbone, J Wenke, T Guda, D Steffens, D Braghirolli, N Maurmann, P Pranke, K Galler, F Brandl, S Kirchhof, M Widbiller, A Eidt, W Buchalla, A Gpferich, G Schmalz, C Kelly, A Miller, S Hollister, R Guldberg, K Gall, S Sharif, J Ai, M Azami, J Verdi, M Atlasi, S Shirian, A Samadikuchaksaraei, Y Cruz, E Muoz, E Gomez-Pachn, J Morales-Corona, J Olayo-Lortia, R Olayo, R Olayo-Valles, M Salehi, M Naseri-Nosar, S Ebrahimi-Barough, M Nourani, A Khojasteh, S Farzamfar, K Mansouri, J Ai, M Heidari, S Bahrami, M Ranjbar-Mohammadi, P Milan, P Xiang, S.-S Wang, M He, Y.-H Han, Z.-H Zhou, D.-L Chen, M Li, L Ma, A Tijore, S Irvine, U Sarig, P Mhaisalkar, V Baisane, S Venkatraman, S Rahmani, F Tabandeh
Abstract
The combined use of polycaprolactone and gelatin has obviated many drawbacks associated with applying them alone. Polycaprolactone provides mechanical strength and buys sufficient time for tissue regeneration without degradation. Simultaneously, gelatin regulates the surface wettability of the composite scaffold. It makes the structure more cytocompatible by its cell recognition sites. Furthermore, these low polymers' cost, biocompatibility, and tuning of degradation time have added to their therapeutic appeal. In the current study, we have reviewed the application of polycaprolactone/gelatin scaffolds in tissue engineering and drug delivery fields, hoping to translate these scaffolds into medicine.