The decoy oligodeoxynucleotide against HIF-1α and STAT5 ameliorates atopic dermatitis-like mouse model
Mi‐Gyeong Gwon, Jaechan Leem, Hyun‐Jin An, Hyemin Gu, Seongjae Bae, Jong Hyun Kim, Kwan‐Kyu Park
Abstract
models. The HIF-1α/STAT5 decoy ODN significantly alleviated cutaneous symptoms similar to AD, including morphology changes, immune cell infiltration, skin barrier dysfunction, and inflammatory response. In the AD model, it also inhibited mast cell infiltration and degranulation in skin tissue. These results suggest that the HIF-1α/STAT5 decoy ODN ameliorates the AD-like disorder and immunoglobulin E (IgE)-induced mast cell activation by disrupting HIF-1α/STAT5 signaling pathways. Taken together, these findings suggest the possibility of HIF-1α/STAT5 as therapeutic targets and their decoy ODN as a potential therapeutic tool for AD.
Topics & Concepts
DecoySTAT5STAT proteinImmunologyDegranulationMast cellAtopic dermatitisImmune systemMedicineSTAT1Cancer researchSignal transductionBiologySTAT3Cell biologyInterferonInternal medicineReceptorDermatology and Skin DiseasesMast cells and histamineAsthma and respiratory diseases