Skeletal Editing of Cyclic Molecules Using Nitrenes
Yi‐An Xu, Shao‐Hua Xiang, Jin‐Teng Che, Yong‐Bin Wang, Bin Tan
Abstract
Comprehensive Summary Nitrenes, as neutral monovalent nitrogen‐centered molecular species, can insert into various bond or remove nitrogen atoms from amines. Nitrene assisted single‐atom skeletal editing, discovered decades ago, provides an efficient approach for the precise alteration of cyclic skeletons. In this review, we briefly summarize early studies on skeletal editing of cyclic frameworks involving nitrene species, and introduce several recent important advances systematically.
Topics & Concepts
ChemistryNitreneMoleculeCombinatorial chemistryOrganic chemistryCatalysisChemical Reactions and MechanismsChemical Reactions and IsotopesSynthesis and Catalytic Reactions