Novel triphenyltin(<scp>iv</scp>) compounds with carboxylato <i>N</i>-functionalized 2-quinolones as promising potential anticancer drug candidates: <i>in vitro</i> and <i>in vivo</i> evaluation
Marijana P. Kasalović, Sanja Jelača, Žiko Milanović, Danijela Maksimović‐Ivanić, Sanja Mijatović, Jelena Lađarević, Bojan Božić, Zoran Marković, Duško Dunđerović, Tobias Rüffer, Robert Kretschmer, Goran N. Kaluđerović, Nebojša Đ. Pantelić
Abstract
, which depends on the specificity of the phenotype and the redox status of the malignant cell line and ranges from the initiation of apoptotic cell death to the induction of differentiation to a more mature cell form. In the syngeneic model of murine melanoma, Ph3SnL1 showed the potential to reduce the tumor volume similar to cisplatin, but in a well-tolerated form and with low systemic toxicity, representing a significant advantage over the conventional drug.
Topics & Concepts
In vivoChemistryIn vitroCisplatinDrugAnticancer drugCombinatorial chemistryStereochemistryPharmacologyBiochemistryBiologyChemotherapyGeneticsBiotechnologyOrganometallic Compounds Synthesis and CharacterizationCrystal structures of chemical compoundsMetal complexes synthesis and properties