Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases
Mohamed Mokhtar, Khadijah Saad Al-Ghamdi, Nesreen S. Ahmed, Dina A. Bakhotmah, Tamer S. Saleh
Abstract
induced apoptotic effect and cell cycle arrest at G2/M phase preventing the mitotic cycle in MCF-7 cells.
Topics & Concepts
MCF-7IC50Cytotoxic T cellChemistryKinaseSorafenibCell cycleCancer cellApoptosisReceptor tyrosine kinaseCancer researchPharmacologyCancerIn vitroBiochemistryBiologyMedicineHuman breastInternal medicineHepatocellular carcinomaSynthesis and biological activitySynthesis and Biological EvaluationEnzyme function and inhibition