Assembly of trifluoromethylated fused tricyclic pyrazoles <i>via</i> cyclization of β-amino cyclic ketones
Nana Wang, Yiming Qiao, Youlong Du, Haibo Mei, Jianlin Han
Abstract
An intramolecular cyclization reaction of β-fluoroalkyl β-amino cyclic ketones with t -BuONO and PPh 3 /CCl 4 has been developed, which provides novel access to trifluoromethylated fused tricyclic pyrazole derivatives.
Topics & Concepts
ChemistryTricyclicDerivatizationDiazoKetoneIntramolecular forceCombinatorial chemistryPyrazoleOrganic chemistryHigh-performance liquid chromatographyCyclopropane Reaction MechanismsFluorine in Organic ChemistrySynthesis and Catalytic Reactions