Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis
Chao Meng, Lingye Zhou, Lin Huang, Qi Gu, Xinyue Du, Cheng Wang, Fanglan Liu, Chunhua Xia
Topics & Concepts
Pregnane X receptorCholesterol 7 alpha-hydroxylaseCell biologyBiologySterol regulatory element-binding proteinHsp90BiochemistryInternal medicineCholesterolEndocrinologyChemistryNuclear receptorSterolTranscription factorHeat shock proteinMedicineGeneCholesterol and Lipid MetabolismPeroxisome Proliferator-Activated ReceptorsPharmacogenetics and Drug Metabolism