One-Pot Sequential Synthesis of 3,3′- or 2,3′-Bis(indolyl)methanes by Using 1,3-Dithiane as the Methylene Source
Kang Dong, Jia Li, Ruipeng Li, Mingming Mao, Jian Liu, Xiaolei Wang, Shouchu Tang
Abstract
A simple and efficient method for structurally diverse symmetrical and unsymmetrical 3,3'- and 2,3'-bisindolylmethanes has been developed through a one-pot sequential reaction using 1,3-dithiane as the methylene source. The important AhR agonists ICZ and malassezin were synthesized with excellent efficiency by this straightforward approach.
Topics & Concepts
DithianeChemistryMethyleneCombinatorial chemistryOrganic chemistrySynthesis of Indole DerivativesMulticomponent Synthesis of HeterocyclesChemical Synthesis and Reactions