Continuously manufactured single-core iron oxide nanoparticles for cancer theranostics as valuable contribution in translational research
Regina Bleul, Abdulkader Baki, Christian Freese, Hendrik Paysen, Olaf Kosch, Frank Wiekhorst
Abstract
in a theranostic application scenario. Finally, first cell viability and apoptosis tests on endothelial cells did not show any cytotoxicity certifying a good biocompatibility of the iron oxide nanoparticles. This microtechnological approach provides reproducible, scalable single core iron oxide nanoparticles as highly performing tracers for MPI diagnosis as well as efficient heat generators for hyperthermia therapy. These preliminary results contribute to translational research in image guided cancer therapy - a further step from basic research to future medicine.
Topics & Concepts
NanoparticleIron oxide nanoparticlesMaterials scienceIron oxideMagnetic nanoparticlesNanotechnologyMagnetic particle imagingParticle sizeMagnetic hyperthermiaChemistryPhysical chemistryMetallurgyCharacterization and Applications of Magnetic NanoparticlesGeomagnetism and Paleomagnetism StudiesMicrofluidic and Bio-sensing Technologies