m <sup>6</sup> A demethylase ALKBH5 controls CD4 <sup>+</sup> T cell pathogenicity and promotes autoimmunity
Jing Zhou, Xingli Zhang, Jiajia Hu, Rihao Qu, Zhibin Yu, Hao Xu, Huifang Chen, Lichong Yan, Chenbo Ding, Qiang Zou, Youqiong Ye, Zhengting Wang, Richard A. Flavell, Huabing Li
Abstract
ALKBH5 maintains CD4 + T cell pathogenicity during autoimmune disease via regulating IFN-γ and CXCL2.
Topics & Concepts
AutoimmunityPathogenicityDemethylaseBiologyAutoimmune diseaseCellDiseaseImmunologyImmune systemGeneticsMicrobiologyMedicineAntibodyPathologyGeneEpigeneticsRNA modifications and cancerCancer-related gene regulationPeptidase Inhibition and Analysis