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Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway

Shuo Zhang, Weijian Liu, Peng Wang, Binwu Hu, Xiao Lv, Songfeng Chen, Baichuan Wang, Zengwu Shao

2021Molecular and Cellular Biochemistry32 citationsDOI

Topics & Concepts

Oxidative stressCell biologyHsp70ApoptosisSenescenceReactive oxygen speciesMitochondrionProgrammed cell deathChemistryBiologyHeat shock proteinBiochemistryGeneSpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationPlant Toxicity and Pharmacological Properties
Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway | Litcius