Introducing charge tag <i>via</i> click reaction in living cells for single cell mass spectrometry
Meihui Zhuang, Zhuanghao Hou, Peiyao Chen, Gaolin Liang, Guangming Huang
Abstract
A charge tag is introduced in living cells <italic>via</italic> a biocompatible click reaction, which greatly increases the sensitivity for single cell mass spectrometry.
Topics & Concepts
Mass spectrometryClick chemistryBiocompatible materialCharge (physics)ChemistryLiving cellCombinatorial chemistryAnalytical Chemistry (journal)ChromatographyPhysicsBiological systemBiologyMedicineBiomedical engineeringQuantum mechanicsMass Spectrometry Techniques and ApplicationsAdvanced biosensing and bioanalysis techniquesAdvanced Proteomics Techniques and Applications