miRNA degradation in the mammalian brain
Chun K. Kim, Toni R. Pak
Abstract
MicroRNAs (miRNAs) are short, noncoding RNAs that are evolutionarily conserved across many different species. miRNA regulation of gene expression, specifically in the context of the mammalian brain, has been well characterized; however, the regulation of miRNA degradation is still a focus of ongoing research. This review focuses on recent findings concerning the cellular mechanisms that govern miRNA degradation, with an emphasis on target-mediated miRNA degradation and how this phenomenon is uniquely poised to maintain homeostasis in neuronal systems.
Topics & Concepts
microRNABiologyContext (archaeology)Mammalian brainComputational biologyNeuroscienceRegulation of gene expressionMechanism (biology)Cell biologyGeneGeneticsPaleontologyPhilosophyEpistemologyMicroRNA in disease regulationCircular RNAs in diseasesCancer-related molecular mechanisms research