Characterization of MET Exon 14 Skipping Alterations (in NSCLC) and Identification of Potential Therapeutic Targets Using Whole Transcriptome Sequencing
So Yeon Kim, Jun Yin, Stephen Bohlman, Phillip Walker, Sanja Đačić, Chul Kim, Hina Khan, Stephen V. Liu, C. Patrick, Misako Nagasaka, Karen L. Reckamp, Jim Abraham, Dipesh Uprety, Feng Wang, Joanne Xiu, Jian Zhang, Haiying Cheng, Balázs Halmos
Abstract
Introduction: ex14) using whole transcriptome sequencing. Methods: amplification were quantified. Immunogenic signatures and potential pathways of invasion were characterized using single-sample gene set enrichment analysis and mRNA gene signatures. Results: ex14 included angiogenesis and apical junction pathways (q < 0.05). Conclusions: ex14 NSCLC.
Topics & Concepts
TranscriptomeExonBiologyExome sequencingCarcinogenesisCancer researchMolecular biologyGeneExon skippingDeep sequencingGene expression profilingGeneticsAlternative splicingMutationGene expressionGenomeCancer Genomics and DiagnosticsLung Cancer Treatments and MutationsGenetic factors in colorectal cancer