Exosomes derived from microRNA-512-5p-transfected bone mesenchymal stem cells inhibit glioblastoma progression by targeting JAG1
Tengfeng Yan, Miaojing Wu, Shigang Lv, Qing Hu, Wenhua Xu, Ailiang Zeng, Kai Huang, Xingen Zhu
Abstract
findings, with BMSC-exosomal miR-512-5p inhibiting glioblastoma growth and prolonging survival in mice. These results suggest that BMSC-derived exosomes transport miR-512-5p into glioblastoma and slow its progression by targeting JAG1. This study reveals a new molecular mechanism for glioblastoma treatment and validates miRNA packaging into exosomes for glioblastoma cell communication.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesmicroRNATransfectionCancer researchGlioblastomaStem cellBiologyCell biologyCell cultureGeneGeneticsMicroRNA in disease regulationExtracellular vesicles in diseaseCircular RNAs in diseases