Current insights into the expression and functions of tumor-derived immunoglobulins
Jing Zhao, Hui Peng, Jie Gao, Anna Nong, Haoming Hua, Shulin Yang, Liying Chen, Xiangsheng Wu, Hao Zhang, Juping Wang
Abstract
Numerous studies have reported expressions of immunoglobulins (Igs) in many human tumor tissues and cells. Tumor-derived Igs have displayed multiple significant functions which are different from classical Igs produced by B lymphocytes and plasma cells. This review will concentrate on major progress in expressions, functions, and mechanisms of tumor-derived Igs, similarities and differences between tumor-derived Igs and B-cell-derived Igs. We also discuss the future research directions of tumor-derived Igs, including their structural characteristics, physicochemical properties, mechanisms for rearrangement and expression regulation, signaling pathways involved, and clinical applications.