The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation
Hashem A. Meriesh, Andrew M. Lerner, Mahesh B. Chandrasekharan, Brian D. Strahl
Abstract
mutant. Consistent with a function for the H4 basic patch in regulating SAGA deubiquitinase activity, we also detected increased SAGA-mediated histone acetylation in H4 basic patch mutants. Our findings uncover that the H4 basic patch has a regulatory function in SAGA-mediated histone modifications.
Topics & Concepts
ChromatinHistone H2BHistone H4HistoneCell biologyBiologyHistone methyltransferaseChemistryGeneticsDNAUbiquitin and proteasome pathwaysEpigenetics and DNA MethylationGenomics and Chromatin Dynamics