Cytomegalovirus Viral Load Threshold to Guide Preemptive Therapy in Hematopoietic Cell Transplant Recipients: Correlation With Cytomegalovirus Disease
Alicja Sadowska‐Klasa, Wendy M. Leisenring, Ajit P. Limaye, Michael Boeckh
Abstract
A systematic review of randomized and observational studies from 2013 to 2023 demonstrated that antiviral preemptive therapy started at cytomegalovirus viral load thresholds between 2 and 3 log10 IU/mL was associated with similar cytomegalovirus disease rates. Thus, viral thresholds in this range appear to effectively protect patients not receiving prophylaxis.
Topics & Concepts
CytomegalovirusHematopoietic cellViral loadMedicineCytomegalovirus infectionDiseaseImmunologyVirologyHematopoietic stem cell transplantationCytomegalovirus infectionsCorrelationViral diseaseHuman cytomegalovirusHerpesviridaeHaematopoiesisVirusBiologyInternal medicineStem cellGeneticsMathematicsGeometryCytomegalovirus and herpesvirus researchHerpesvirus Infections and TreatmentsParvovirus B19 Infection Studies