Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase
Serena Massari, Chiara Bertagnin, Maria Chiara Pismataro, Anna Donnadio, Giulio Nannetti, Tommaso Felicetti, Stefano Di Bona, Maria Giulia Nizi, Leonardo Tensi, Giuseppe Manfroni, Marı́a Isabel Loza, Stefano Sabatini, Violetta Cecchetti, José Brea, Laura Goracci, Arianna Loregian, Oriana Tabarrini
Topics & Concepts
PyrimidineChemistryCarboxamideMoietyPolymeraseLead compoundStereochemistryRNA polymeraseStructure–activity relationshipCombinatorial chemistryVirologyRNABiochemistryIn vitroBiologyDNAGeneInfluenza Virus Research StudiesRNA and protein synthesis mechanismsinterferon and immune responses