Selective Reduction of Quinolinones Promoted by a SmI<sub>2</sub>/H<sub>2</sub>O/MeOH System
Dengbing Xie, Songlin Zhang
Abstract
The selective reduction of quinolin-2(1H)-ones promoted by a SmI2/H2O/MeOH system is reported for the first time. The reaction is effectively carried out to afford 3,4-dihydroquinoline-2(1H)-ones under mild conditions in a one-pot fashion with good to excellent yields.
Topics & Concepts
ChemistryReduction (mathematics)Selective reductionChemical reductionMedicinal chemistryCombinatorial chemistryOrganic chemistryPhysical chemistryCatalysisElectrochemistryGeometryMathematicsElectrodeCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis