LCP1 knockdown in monocyte-derived macrophages: mitigating ischemic brain injury and shaping immune cell signaling and metabolism
Yan Wang, Qianqian Yin, Decao Yang, Haojie Jin, Yang Yao, Jibing Song, Cuiying Liu, Yu Nie, Hao Yin, Wei Wang, Baohui Xu, Lixiang Xue, Xunming Ji, Xiaoyuan Chen, Heng Zhao
Abstract
These findings contribute to a deeper understanding of LCP1 in the context of ischemic stroke and provide valuable insights into potential therapeutic strategies targeting LCP1 and metabolic pathways, aiming to attenuating neuroinflammation and lymphopenia.
Topics & Concepts
Immune systemCell biologyGene knockdownBiologyCancer researchAnaerobic glycolysisProtein kinase BGlycolysisSignal transductionChemistryApoptosisImmunologyMetabolismBiochemistryNeuroinflammation and Neurodegeneration MechanismsCancer-related molecular mechanisms researchImmune cells in cancer