Arachidonate 5-lipoxygenase is essential for biosynthesis of specialized pro-resolving mediators and cardiac repair in heart failure
Ganesh V. Halade, Vasundhara Kain, Shahriare Hossain, Vibhu Parcha, Nita A. Limdi, Pankaj Arora
Abstract
Arachidonate 5-lipoxygenase (ALOX5) is critical in synthesizing specialized pro-resolving mediators that facilitate cardiac repair after cardiac injury. Thus, ALOX5 orchestrates the overlapping phases of inflammation and resolution to facilitate myocardium healing in cardiac repair postmyocardial infarction.
Topics & Concepts
Heart failureInflammationLipoxygenaseArachidonate 5-lipoxygenaseMyocardial infarctionMedicineCardiologyInternal medicineChemistryEnzymeBiochemistryArachidonic acidCardiac Ischemia and ReperfusionCardiovascular Function and Risk FactorsNitric Oxide and Endothelin Effects