Exogenous supplement of glucagon like peptide-1 protects the heart against aortic banding induced myocardial fibrosis and dysfunction through inhibiting mTOR/p70S6K signaling and promoting autophagy
Ronghua Zheng, Weiwei Zhang, Ye-Nan Ji, Xiaojie Bai, Cai-Ping Yan, Jin Wang, Feng Bai, Zhi‐Qing Zhao
Topics & Concepts
LiraglutideAutophagyPI3K/AKT/mTOR pathwaySirolimusEndocrinologyInternal medicineMedicineFibrosisCardiac fibrosisRibosomal protein s6mTORC1Mechanistic target of rapamycinMyocardial fibrosisPhosphorylationPharmacologyBiologySignal transductionP70-S6 Kinase 1Cell biologyDiabetes mellitusApoptosisType 2 diabetesBiochemistryDiabetes Treatment and ManagementCardiovascular Function and Risk FactorsPancreatic function and diabetes