TFAM depletion overcomes hepatocellular carcinoma resistance to doxorubicin and sorafenib through AMPK activation and mitochondrial dysfunction
Ying Zhu, Jianguo Xu, Wei Hu, Fang Wang, Yan Zhou, Wen Xu, Wei Gong, Lichun Shao
Topics & Concepts
TFAMBiologyCancer researchSorafenibMitochondrial biogenesisAMPKHepatocellular carcinomaOncogeneCarcinogenesisCell cultureMitochondrionApoptosisMolecular biologyCell cycleKinaseCell biologyProtein kinase ACancerGeneticsMitochondrial Function and PathologyATP Synthase and ATPases ResearchCancer, Hypoxia, and Metabolism