Recent Advances in Cardiac Patches: Materials, Preparations, and Properties
Yi Zhang, Wenying Mu, Yanping Zhang, Xuetao He, Yiming Wang, Hongyu Ma, Tianyang Zhu, Aoyuan Li, Qinzheng Hou, Weimin Yang, Yumei Ding, Seeram Ramakrishna, Haoyi Li
Abstract
Cardiac patches are biomaterials that can be used for transplantation and repair of damaged myocardium by combining seed cells with the ability to form cardiomyocytes and suitable scaffold materials. On the one hand, they provide temporary support to the infarcted area, and on the other hand, they repair the damaged myocardium by delivering cells or bioactive factors to integrate with the host, which have gradually become a hot research topic in recent years. This paper summarizes the structural properties of natural myocardium and reviews the recent research progress of cardiac patches, including the seed cells and scaffold materials used in patch preparation, as well as the main methods of scaffold preparation and the structure properties of various scaffolds. In addition, a comprehensive analysis of the problems faced in the clinical implementation of cardiac patches is presented. Finally, we look forward to the development of cardiac patches and point out that precisely tunable anisotropic tissue engineering scaffolds close to natural myocardial tissue will become an important direction for future research.