The intricate microbial–gut–brain axis in Alzheimer's disease: a review of microbiota-targeted strategies
Shu Zhang, Zhenghao Wu, Shuling Zhang, Yingjun Ru, Qinwen Wang, Haoxiang Tong, Qihan Qin, Qing Yan, Ziwei Li, Guoqing Wu
Abstract
Gut-targeted regulatory strategies, such as probiotics, prebiotics and so on, can exert beneficial effects on Alzheimer's disease via the endocrine, neural, metabolic, and immune systems of the microbiota-gut-brain axis.
Topics & Concepts
Gut floraMicrobiomeGut–brain axisNeuroscienceImmune systemFunction (biology)DiseaseEndocrine systemBiologyGut microbiomeBioinformaticsBrain functionNeuroimmunologyMechanism (biology)InflammationCognitionHormoneNeuroinflammationMedicineComputational biologyImmunologyMetabolic pathwaySignal transductionDysbiosisLipid signalingReview articleEnteroendocrine cellGut microbiota and healthTryptophan and brain disordersDiet and metabolism studies