Accelerative effect of topical <i>Zataria multiflora</i> essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis
Mohammad Reza Farahpour, Sara Sheikh, Elham Kafshdooz, Ali Sonboli
Abstract
CONTEXT: Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection. OBJECTIVE: This study evaluates the effects of an ointment prepared from ZME (ZMEO) on infected wounds. MATERIALS AND METHODS: (MG), (3) therapeutic ointment containing 2% ZMEO and (4) therapeutic ointment containing 4% ZMEO, for 21 days. Wound contraction, total bacterial count, histopathological parameters, antioxidant activity, qRT-PCR analysis for expression of IL-1β, TNF-α, VEGF, IGF-1, TGF-β, IL-10, and FGF-2 mRNA levels were assessed on days 3, 7, and 14 following the wounding. RESULTS: < 0.05). DISCUSSION AND CONCLUSION: ZMEO accelerated the healing process of infected wounds by shortening the inflammatory factors and increasing proliferative phase. Applying ZMEO only and/or in combination with chemical agents for the treatment of wound healing could be suggested.