Nicardipine sensitizes temozolomide by inhibiting autophagy and promoting cell apoptosis in glioma stem cells
Jia Shi, Xuchen Dong, Haoran Li, Haiyang Wang, Qianqian Jiang, Liang Liu, Liping Wang, Jun Dong
Abstract
. Repurposing of nicardipine can help to improving therapeutic effect of TMZ against GBM, which deserves further clinical investigations.
Topics & Concepts
NicardipineTemozolomideAutophagyApoptosisStem cellGliomaCancer researchPharmacologyChemistryMedicineCell biologyBiologyInternal medicineCalciumBiochemistryAutophagy in Disease and TherapyGlioma Diagnosis and TreatmentMicroRNA in disease regulation