A Review of the Abscopal Effect in the Era of Immunotherapy
Edward Nabrinsky, Jason Macklis, Jacob D. Bitran
Abstract
The abscopal effect is a systemic immune response mediated by the effects of radiation on the immune system. This effect has been observed in a number of cancer types in addition to lung cancer, including but not limited to renal cell carcinoma, hepatocellular carcinoma, lymphoma, and melanoma. The combination of radiation therapy and immune checkpoint inhibition (ICI) acts at several stages of the antitumor response, suggesting a mechanism of synergy between the two modalities. This review focuses on recent advances in the understanding of the effect of radiation and immunotherapy in the context of the abscopal effect.
Topics & Concepts
MedicineAbscopal effectImmunotherapyContext (archaeology)Immune systemMelanomaBystander effectRadiation therapyImmunologyLung cancerCancer immunotherapyCancer researchOncologyInternal medicineBiologyPaleontologyEffects of Radiation ExposureColorectal and Anal CarcinomasCancer Immunotherapy and Biomarkers