A general transition metal binding aptamer following the Irving–Williams series
Jin Wang, Yunus A. Kaiyum, Sihan Wang, Xiangmei Li, Hongtao Lei, Philip E. Johnson, Juewen Liu
Abstract
from the strand-displacement assay was 76 nM. The Co-1 aptamer is the first reported aptamer to follow the Irving-Williams series, although this series is very prevalent in proteins. This aptamer can thus serve as a model system for understanding metal binding by DNA and can also be a general first-row transition metal sensing element.
Topics & Concepts
AptamerSeries (stratigraphy)Transition (genetics)ChemistryBiologyBiochemistryGeneticsGenePaleontologyAdvanced biosensing and bioanalysis techniquesMolecular Junctions and NanostructuresMolecular Sensors and Ion Detection