A multi-residue chiral liquid chromatography coupled with tandem mass spectrometry method for analysis of antifungal agents and their metabolites in aqueous environmental matrices
Rawiwan Wattanayon, Barbara Kasprzyk‐Hordern
Abstract
) MQLs for most analytes. The method was applied in selected environmental samples. The following analytes were quantified: fluconazole, terbinafine, N-desmethyl-carboxyterbinafine, tebuconazole, epoxiconazole, propiconazole and N-deacetyl ketoconazole. They were predominantly present in the aqueous environment (as opposed to wastewater) with sources linked with animal and plant protection rather than usage in humans. Interestingly, chiral fungicides quantified in river water were enriched with one enantiomer. This might have consequences in terms of their ecological effects which warrants further study.
Topics & Concepts
AntifungalChemistryChromatographyTandem mass spectrometryResidue (chemistry)Liquid chromatography–mass spectrometryAqueous solutionMass spectrometryTandemCombinatorial chemistryOrganic chemistryMaterials scienceBiologyComposite materialMicrobiologyAnalytical Chemistry and ChromatographyPharmaceutical and Antibiotic Environmental ImpactsAnalytical chemistry methods development