Shikonin triggers GSDME-mediated pyroptosis in tumours by regulating autophagy via the ROS–MAPK14/p38α axis
Xiaoli Ju, Heng Zhang, Jiayou Wang, Zhonghe Sun, Lanfang Guo, Qiang Wang
Topics & Concepts
PyroptosisAutophagyCell biologyProgrammed cell deathApoptosisChemistryReactive oxygen speciesp38 mitogen-activated protein kinasesViability assayCancer researchBiologySignal transductionMAPK/ERK pathwayBiochemistryInflammasome and immune disordersBioactive Compounds and Antitumor AgentsCell death mechanisms and regulation