Color Tuning of Fluorogens for FAST Fluorogen‐Activating Protein
Ivan N. Myasnyanko, Alexey S. Gavrikov, Snizhana O. Zaitseva, Alexander Yu. Smirnov, Elvira R. Zaitseva, Анатолий И. Соколов, Kseniya K. Malyshevskaya, Надежда С. Балеева, Alexander S. Mishin, Михаил С. Баранов
Abstract
Using benzylidene imidazolone core, we created a panel of color-shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live-cell protein labeling. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of a pallet of live-cell fluorogenic labeling tools.
Topics & Concepts
PalletChemistryBiophysicsNanotechnologyCombinatorial chemistryComputer scienceMaterials scienceEngineeringBiologyMechanical engineeringClick Chemistry and ApplicationsChemical Synthesis and AnalysisFluorine in Organic Chemistry