Visible-Light-Induced Tandem Radical Brominative Addition/Cyclization of Activated Alkynes with CBr<sub>4</sub> for the Synthesis of 3-Bromocoumarins
Chenyang Yan, Zhengwei Wu, Xiaoyu He, Yuhong Ma, Xiao-Rong Peng, Long Wang, Qing‐Qing Yang
Abstract
A visible-light-induced tandem radical brominative addition/spiro-cyclization/1,2-ester migration of activated alkynes with CBr4 is developed. This protocol features good functional group tolerance, operational simplicity, and mild reaction conditions without the use of catalysts and external additives, providing easy access to valuable 3-bromocoumarins in generally high yields.
Topics & Concepts
TandemCatalysisChemistryVisible spectrumFunctional groupRadical cyclizationCombinatorial chemistryReaction conditionsProtocol (science)PhotochemistryOrganic chemistryMaterials scienceOptoelectronicsMedicinePolymerComposite materialAlternative medicinePathologyRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods