Infection of Glia by Human Pegivirus Suppresses Peroxisomal and Antiviral Signaling Pathways
M. A. L. Doan, A. Roczkowsky, M. Smith, G. Blevins, F. K. H. van Landeghem, B. B. Gelman, W. G. Branton, J. T. Stapleton, T. C. Hobman, C. Power
Abstract
Human pegiviruses are detected in 1 to 5% of the general population, principally infecting leukocytes, although their effects on human health remain uncertain. Here, we show that human pegivirus infects specific neural cell types in culture and human brain and, like other neurotropic flaviviruses, causes suppression of peroxisome and antiviral signaling pathways, which could favor ongoing viral infection and perhaps confer susceptibility to the development of neurological disease.
Topics & Concepts
BiologyPeroxisomeVirologySignal transductionFlaviviridaeHepacivirusCell cultureHuman brainHuman liverVirusNeurogliaCell biologyCellImmunologyCentral nervous systemViral diseaseMitochondrionFlavivirusCell signalingHEK 293 cellsHepatitis C virusMolecular biologyViral infectionViral replicationMosquito-borne diseases and controlInfectious Encephalopathies and EncephalitisRespiratory viral infections research