Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and <i>in vivo</i> behaviour
Thomas J. L’Ecuyer, Nicolas Bia, Pierre Bürckel, Cédric Loubat, Alain Graillot, Johanne Séguin, Yohann Corvis, Jianhua Liu, Lucie Valéro, Daniel Scherman, Nathalie Mignet, Cyrille Richard
Abstract
biodistribution study has been performed. Among them ZGOpPEG exhibits a long circulation time, corresponding to low protein adsorption, while presenting an effective one-step process in aqueous medium with a low hydrodynamic diameter increase. This new method is much more advantageous than another strategy we reported previously that used a two-step PEG silane coating performed in an organic solvent (dimethylformamide) for which the final hydrodynamic diameter was twice the initial diameter.
Topics & Concepts
In vivoPersistent luminescenceNanoparticleMaterials scienceBiodistributionCoatingPolymerNanotechnologySurface modificationLuminescenceMononuclear phagocyte systemMiniemulsionPolyethylene glycolChemistryOrganic chemistryBiotechnologyMonomerImmunologyBiologyPhysical chemistryOptoelectronicsComposite materialThermoluminescenceNanoplatforms for cancer theranosticsLuminescence Properties of Advanced MaterialsLuminescence and Fluorescent Materials