<i>Cosmc</i> deficiency causes spontaneous autoimmunity by breaking B cell tolerance
Junwei Zeng, Rajindra P. Aryal, Kathrin Stavenhagen, Chi Luo, Renyan Liu, Xiaohui Wang, Jiaxuan Chen, Hao Li, Yasuyuki Matsumoto, Yingchun Wang, Jianmei Wang, Tongzhong Ju, Richard D. Cummings
Abstract
, through control of core 1 O-glycans, is a previously unidentified immune checkpoint gene in maintaining B cell tolerance.
Topics & Concepts
AutoimmunityBiologyImmunologyGeneticsAntibodyImmunodeficiency and Autoimmune DisordersImmune Cell Function and InteractionCytomegalovirus and herpesvirus research