Endogenous Retroviruses in Nervous System Disorders
Victoria Gröger, Alexander Emmer, Martin S. Staege, Holger Cynis
Abstract
Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.
Topics & Concepts
Amyotrophic lateral sclerosisPathogenesisNervous systemEndogenyMultiple sclerosisEndogenous retrovirusMedicineCentral nervous systemImmunologyBioinformaticsNeuroscienceBiologyDiseasePathologyGeneticsGeneInternal medicineGenomeChromosomal and Genetic VariationsCRISPR and Genetic EngineeringViral Infections and Immunology Research