Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended <i>In Cellulo</i>, <i>In Silico</i>, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
Anna Pasieka, Dawid Panek, Natalia Szałaj, Alba Espargaró, Anna Więckowska, Barbara Malawska, Raimon Sabaté, Marek Bajda
Abstract
could inhibit the amyloid aggregation process at several steps and also displayed disaggregating properties. These results may help to design the next generations of dual or selective aggregation inhibitors.
Topics & Concepts
In silicoChemistryIC50Docking (animal)Protein aggregationAmyloid (mycology)In vitroBiochemistryGeneMedicineInorganic chemistryNursingAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods