Theabrownin from Fu Brick tea ameliorates high-fat induced insulin resistance, hepatic steatosis, and inflammation in mice by altering the composition and metabolites of gut microbiota
Zhongting Lu, Yan Zheng, Juan Zheng, Qijian Liang, Qingcai Zhen, Mengjie Cui, Haoru Yang, Haotian Wu, Cuixia Tian, Kangming Zhu, Chunyong Bian, Lei Du, Hao Wu, Xin Guo
Abstract
, L-ornithine, α-ketoglutarate, or glutamine significantly reduced lipopolysaccharide (LPS)-induced inflammation in macrophages. Therefore, our results suggest that TB can reduce adiposity, systemic insulin resistance, and liver inflammation induced by a HFD through altering gut microbiota and improving the intestinal tight junction integrity. The metabolites of gut microbiota might also play a role in ameliorating the HFD-induced phenotype by TB.
Topics & Concepts
Insulin resistanceGut floraSteatosisInflammationGlutamineEndocrinologyLipopolysaccharideInternal medicineBiologyInsulinImmunologyBiochemistryMedicineAmino acidTea Polyphenols and EffectsTryptophan and brain disordersGut microbiota and health