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IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis

Cheng An, Fei Sun, Can Liu, Shaojun Huang, Tao Xu, Chengxin Zhang, Shenglin Ge

2023International Immunopharmacology85 citationsDOI

Topics & Concepts

Cell biologyPyroptosisBiologyMolecular biologyMitochondrionProgrammed cell deathApoptosisBiochemistryinterferon and immune responsesInflammasome and immune disordersRNA modifications and cancer
IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis | Litcius