Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis
Prashant Chandrasekharan, Renesmee Kuo, K. L. Barry Fung, Chinmoy Saayujya, Jacob Bryan, Mariam Yousuf, Benjamin Fellows, Caylin Colson, Quincy Huynh, Owen Doyle, Allison Hartley, Khadija Yousuf, Patrick Goodwill, Steven Conolly
Abstract
Magnetic particle imaging (MPI) is a new tracer-based imaging modality that is useful in diagnosing various pathophysiology related to the vascular system and for sensitive tracking of cytotherapies. MPI uses nonradioactive and easily assimilated nanometer-sized iron oxide particles as tracers. MPI images the nonlinear Langevin behavior of the iron oxide particles and has allowed for the sensitive detection of iron oxide-labeled therapeutic cells in the body. This review will provide an overview of MPI technology, the tracer, and its use in vascular imaging and cytotherapies using molecular targets.