Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial
Boubacar Coulibaly, Dramane Kiemde, Guillaume Zonou, Ali Sié, Clarisse Dah, Mamadou Bountogo, Jessica Brogdon, Huiyu Hu, Elodie Lebas, Travis C. Porco, Thuy Doan, Thomas M. Lietman, Catherine E. Oldenburg
Abstract
We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months.
Topics & Concepts
AzithromycinErythromycinMedicineStreptococcus pneumoniaePlaceboClindamycinRandomized controlled trialInternal medicineAntibioticsCarriageMicrobiologyBiologyPathologyAlternative medicinePneumonia and Respiratory InfectionsRespiratory and Cough-Related ResearchBacterial Infections and Vaccines