Effects of Exopolysaccharides from <i>Lactiplantibacillus plantarum</i> JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice
Ji Wang, Meihe Li, Yawen Gao, Hongmei Li, Fang Li, Chunlei Liu, Xiaoting Liu, Weihong Min
Abstract
regulating the ratio of villous height to crypt depth and upregulating the expression of tight-junction proteins. Meanwhile, EPS103 promoted the generation of short-chain fatty acids (SCFAs) and modulated the constituents of gut microbiota. These results suggested that EPS103 may modulate the intestinal immunoresponse relying on the regulation of SCFA production and gut microbiota in immunosuppressed mice, resulting in the activation of systemic immunity.
Topics & Concepts
Immune systemOxidative stressMucinSecretionMicrobiologyImmunoglobulin AMucin 2BiologyImmunologySmall intestineChemistryBiochemistryImmunoglobulin GGene expressionGeneGut microbiota and healthProbiotics and Fermented FoodsHelicobacter pylori-related gastroenterology studies