Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity
Xiaoying Jiang, Jianan Guo, Yangjing Lv, Chuansheng Yao, Changjun Zhang, Zhisheng Mi, Yuan Shi, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie
Topics & Concepts
ChemistryAntioxidantMonoamine oxidase BMonoamine oxidaseIC50PharmacologyDeferiproneChelationBiochemistryStereochemistryEnzymeIn vitroDeferoxamineOrganic chemistryMedicineAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesMedicinal Plants and Neuroprotection