Silacyclization through palladium-catalyzed intermolecular silicon-based C(sp<sup>2</sup>)–C(sp<sup>3</sup>) cross-coupling
Ying Qin, Lianghui Li, Jin-Yuan Liang, Kailong Li, Dongbing Zhao
Abstract
]oxepines with good functional group tolerance. The key to success for this reaction is that silicon atoms have a stronger affinity for oxygen nucleophiles than carbon nucleophiles, and silacyclobutanes (SCBs) have inherent ring-strain-release Lewis acidity.
Topics & Concepts
PalladiumCatalysisIntermolecular forceSiliconCoupling (piping)ChemistryPhysicsCrystallographyMaterials scienceMoleculeOrganic chemistryMetallurgyCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods