Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma
Steven Powell, Miroslaw Mazurczak, Elie G. Dib, Jonathon S. Bleeker, L. Geeraerts, Matthew Tinguely, Michele Lohr, Steven McGraw, Ashley W. Jensen, Christie Ellison, Lora Black, Susan E. Puumala, Valerie Reed, W. Keith Miskimins, John H. Lee, William C. Spanos
Topics & Concepts
MedicinePlaceboInternal medicineHead and neck squamous-cell carcinomaAdverse effectChemoradiotherapyClinical endpointGastroenterologyToxicityHead and neck cancerLactate dehydrogenasePharmacologyChemotherapyOncologyRadiation therapyRandomized controlled trialPathologyBiologyAlternative medicineBiochemistryEnzymeCancer, Hypoxia, and MetabolismLung Cancer Research StudiesHead and Neck Cancer Studies