SIRT1 deficiency increases O-GlcNAcylation of tau, mediating synaptic tauopathy
Xiaomin Yin, Yuanyuan Li, Xing Fan, Fang Huang, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Qun Gu, Liye Xia, Junze Bao, Xiaochuan Wang, Fei Liu, Wei Qian
Topics & Concepts
TauopathyNeuroscienceHyperphosphorylationPhosphorylationTau proteinSirtuin 1Dendritic spineBiologyAlzheimer's diseaseDiseaseCell biologyPsychologyInternal medicineNeurodegenerationMedicineBiochemistryHippocampal formationDownregulation and upregulationGeneAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchCalcium signaling and nucleotide metabolism