<i>In Vitro</i> Selection Identifies Staphylococcus aureus Genes Influencing Biofilm Formation
Dustin R. Long, Kelsi Penewit, Hsin‐Yu Lo, Jared Almazan, Elizabeth A. Holmes, Andrew Bryan, Daniel J. Wolter, Janessa D. Lewis, Adam Waalkes, Stephen J. Salipante
Abstract
Staphylococcus aureus generates biofilms during many chronic human infections, which contributes to its growth and persistence in the host. Multiple genes and pathways necessary for S. aureus biofilm production have been identified, but knowledge is incomplete, and little is known about spontaneous mutations that increase biofilm formation as infection progresses.
Topics & Concepts
Staphylococcus aureusBiologyBiofilmMicrobiologyIn vitroSelection (genetic algorithm)GeneStaphylococcal infectionsBacteriaGeneticsComputer scienceArtificial intelligenceBacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus