Ruthenium‐Catalyzed <i>meta</i>‐Selective C−H Nitration of Biologically Important Aryltetrazoles
Jian Chen, Tianle Huang, Xinrui Gong, Zhujun Yu, Yuesen Shi, Yu‐Hang Yan, Yang Zheng, Xuexin Liu, Guo‐Bo Li, Yong Wu
Abstract
Abstract The first example of tetrazole‐directed meta ‐selective C−H nitration is described. This transformation provided a straightforward approach for the synthesis of biologically important m ‐nitroaryltetrazoles in moderate to excellent yields with good functional group compatibility. In addition, new metallo‐β‐lactamase inhibitors were obtained by further transformation of the synthesized m ‐nitroaryltetrazoles. magnified image
Topics & Concepts
ChemistryNitrationRutheniumCombinatorial chemistryTetrazoleCatalysisBiological activityTransformation (genetics)NitroFunctional groupStereochemistryOrganic chemistryBiochemistryIn vitroGenePolymerAlkylCatalytic C–H Functionalization MethodsChemical Synthesis and ReactionsAsymmetric Hydrogenation and Catalysis